1022 - Mutations of the P53 Tumor Suppressor Gene in Rheumatoid Arthritis Synovium
نویسندگان
چکیده
*Han, C Whan (A-Taejon St. Mary's Hospital); +**Kim, J Man; *Kim, W Yoo; *Kim, J Young; *Kim, H Kwan; *Ryu, J Duk; *Lee, K Won *Department of Orthopaedic Surgery, Taejon St. Mary's Hospital, Taejon, South Korea. +**Department of Orthopaedic Surgery, KangNam St. Mary's Hospital, Seoul, South Korea. Kang-Nam St. Mary's Hospital Department of Orthopaedic Surgery 505, Ban Po-Dong, Seo Cho-Ku Seoul, South Korea 137-040, 82-2-590-1464, Fax: 82-2-535-9834, [email protected]
منابع مشابه
p53 tumor suppressor gene mutations in fibroblast-like synoviocytes from erosion synovium and non-erosion synovium in rheumatoid arthritis
Abnormalities in the p53 tumor suppressor gene have been detected in rheumatoid arthritis (RA) and could contribute to the pathogenesis of chronic disease. To determine whether synoviocytes from invasive synovium in RA have an increased number of mutations compared with non-erosion synoviocytes, p53 cDNA subclones from fibroblast-like synoviocytes (FLS) derived from erosion and non-erosion site...
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The factors that regulate the perpetuation and invasiveness of rheumatoid synovitis have been the subject of considerable inquiry, and the possibility that nonimmunologic defects can contribute to the disease has not been rigorously addressed. Using a mismatch detection system, we report that synovial tissue from the joints of severe chronic rheumatoid arthritis patients contain mutant p53 tran...
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Objective(s) P53 is an important tumor suppressor, which is mutated in later stages of many cancers and leads to resistance to chemotherapy. The aim of this study was to reveal mutations of TP53 in colorectal cancer in Kerman province. Materials and Methods A total of Forty-three colon cancer specimens as paraffin block or fresh tissues, which passed stage IIIA, were selected. Three exons 5,...
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OBJECTIVE In order to study the role of the p53 tumour suppressor gene in the proliferation of rheumatoid arthritis (RA) synovium, we analysed the mutation of p53 in the synovial fibroblast-like type B synoviocyte from RA patients. METHODS Synovial fibroblast-like type B synoviocytes were prepared from the synovial tissues from nine Japanese patients with RA. The p53 cDNA region from exons 4-...
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The knowledge of transcription factors and proto-oncogenes has influenced the understanding of cell regulation, cell cycle, and apoptotic cell death in rheumatoid arthritis (RA) synovium. In addition, the development of normal synovial fibroblasts into transformed-appearing aggressive synovial fibroblasts may be triggered by the lack of antiproliferative factors, such as p53, p53-associated mol...
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